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ZIC1 has not been detected as a mutational cancer driver

ZIC1
Ensembl id ENSG00000152977
Mutated samples
Coding Sequence 186 (2.7%)
Protein Affecting 74 (1.1%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all ZIC1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Lung squamous cell carcinoma No 28 16 9.20
Head and neck squamous cell carcinoma No 29 13 3.47
Lung adenocarcinoma No 27 8 2.05
Esophageal carcinoma No 16 8 5.48
Cutaneous melanoma No 18 6 1.63
Bladder carcinoma No 5 4 4.08
Stomach adenocarcinoma No 9 4 2.48
Glioblastoma multiforme No 7 3 0.79
Prostate adenocarcinoma No 3 2 0.82
Medulloblastoma No 2 2 0.95
Small cell lung carcinoma No 3 2 2.90
Hepatocarcinoma No 6 1 1.11
Breast carcinoma No 6 1 0.09
Neuroblastoma No 2 1 0.48
Uterine corpus endometrioid carcinoma No 7 1 0.43
Non small cell lung carcinoma No 2 1 3.23
Serous ovarian adenocarcinoma No 1 1 0.32
Renal clear cell carcinoma No 2 0 0.00
Thyroid carcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 8 0 0.00
Lower grade glioma No 1 0 0.00
Colorectal adenocarcinoma No 3 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence