ZFP36L2 mutations in 7 cancer types possibly contribute to the detection of the gene in the PAN-cancer anlaysis:: Bladder carcinoma, Breast carcinoma, Lung squamous cell carcinoma, Renal clear cell carcinoma, Cutaneous melanoma, Uterine corpus endometrioid carcinoma, Esophageal carcinoma

Ensembl id ENSG00000152518
Mutated samples
Coding Sequence 47 (0.7%)
Protein Affecting 33 (0.5%)
Mode of action Loss of function
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all ZFP36L2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Lung squamous cell carcinoma Yes 6 6 3.45
Cutaneous melanoma Yes 7 5 1.36
Bladder carcinoma Yes 5 3 3.06
Breast carcinoma Yes 4 3 0.26
Renal clear cell carcinoma Yes 3 3 0.72
Uterine corpus endometrioid carcinoma Yes 4 3 1.30
Esophageal carcinoma Yes 3 3 2.05
Head and neck squamous cell carcinoma No 7 4 1.07
Neuroblastoma No 1 1 0.48
Colorectal adenocarcinoma No 1 1 0.44
Acute lymphocytic leukemia No 1 1 0.82
Lung adenocarcinoma No 1 0 0.00
Hepatocarcinoma No 2 0 0.00
Multiple myeloma No 1 0 0.00
Glioblastoma multiforme No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence