YTHDF2 has not been detected as a mutational cancer driver

Ensembl id ENSG00000198492
Mutated samples
Coding Sequence 31 (0.5%)
Protein Affecting 24 (0.4%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all YTHDF2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 8 6 1.63
Lung adenocarcinoma No 5 4 1.02
Bladder carcinoma No 3 3 3.06
Medulloblastoma No 2 2 0.95
Uterine corpus endometrioid carcinoma No 2 2 0.87
Head and neck squamous cell carcinoma No 2 2 0.53
Lung squamous cell carcinoma No 2 1 0.57
Renal clear cell carcinoma No 1 1 0.24
Serous ovarian adenocarcinoma No 1 1 0.32
Stomach adenocarcinoma No 2 1 0.62
Esophageal carcinoma No 1 1 0.68
Pylocytic astrocytoma No 1 0 0.00
Glioblastoma multiforme No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence