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XRN1 is detected as a mutational cancer driver in 1 cancer type: Cutaneous melanoma

XRN1
Ensembl id ENSG00000114127
Mutated samples
Coding Sequence 101 (1.5%)
Protein Affecting 78 (1.1%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
CM F
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all XRN1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma Yes 17 15 4.07
Breast carcinoma No 12 11 0.96
Uterine corpus endometrioid carcinoma No 8 8 3.48
Stomach adenocarcinoma No 8 8 4.97
Head and neck squamous cell carcinoma No 9 7 1.87
Lung adenocarcinoma No 9 5 1.28
Small cell lung carcinoma No 5 4 5.80
Lung squamous cell carcinoma No 4 3 1.72
Renal clear cell carcinoma No 5 3 0.72
Serous ovarian adenocarcinoma No 3 3 0.95
Colorectal adenocarcinoma No 3 3 1.31
Bladder carcinoma No 4 2 2.04
Esophageal carcinoma No 3 2 1.37
Prostate adenocarcinoma No 1 1 0.41
Hepatocarcinoma No 4 1 1.11
Thyroid carcinoma No 3 1 0.31
Multiple myeloma No 1 1 1.45
Chronic lymphocytic leukemia No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence