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XPO1 is detected as a mutational cancer driver in 1 cancer type: Chronic lymphocytic leukemia

XPO1
Ensembl id ENSG00000082898
Mutated samples
Coding Sequence 63 (0.9%)
Protein Affecting 46 (0.7%)
Mode of action Unclassified
Known driver Yes
Cancer type Signals (Biases)
CLL CF
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all XPO1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Chronic lymphocytic leukemia Yes 8 8 2.76
Breast carcinoma No 9 7 0.61
Renal clear cell carcinoma No 6 6 1.44
Head and neck squamous cell carcinoma No 7 6 1.60
Bladder carcinoma No 4 3 3.06
Cutaneous melanoma No 8 3 0.81
Lung adenocarcinoma No 2 2 0.51
Lung squamous cell carcinoma No 2 2 1.15
Uterine corpus endometrioid carcinoma No 5 2 0.87
Stomach adenocarcinoma No 4 2 1.24
Hepatocarcinoma No 2 1 1.11
Multiple myeloma No 1 1 1.45
Lower grade glioma No 1 1 0.59
Glioblastoma multiforme No 1 1 0.26
Esophageal carcinoma No 2 1 0.68
Serous ovarian adenocarcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence