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XIRP1 has not been detected as a mutational cancer driver

XIRP1
Ensembl id ENSG00000168334
Mutated samples
Coding Sequence 157 (2.3%)
Protein Affecting 116 (1.7%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all XIRP1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 66 48 13.01
Breast carcinoma No 8 8 0.70
Head and neck squamous cell carcinoma No 14 8 2.13
Lung adenocarcinoma No 10 7 1.79
Lung squamous cell carcinoma No 9 7 4.02
Uterine corpus endometrioid carcinoma No 9 6 2.61
Serous ovarian adenocarcinoma No 4 4 1.27
Stomach adenocarcinoma No 5 4 2.48
Colorectal adenocarcinoma No 4 4 1.75
Prostate adenocarcinoma No 3 3 1.23
Bladder carcinoma No 4 3 3.06
Renal clear cell carcinoma No 3 3 0.72
Lower grade glioma No 3 3 1.78
Small cell lung carcinoma No 3 2 2.90
Acute myeloid leukemia No 2 1 0.51
Pancreas adenocarcinoma No 1 1 0.47
Neuroblastoma No 1 1 0.48
Non small cell lung carcinoma No 1 1 3.23
Glioblastoma multiforme No 3 1 0.26
Esophageal carcinoma No 3 1 0.68
Multiple myeloma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence