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WNK3 has not been detected as a mutational cancer driver

WNK3
Ensembl id ENSG00000196632
Mutated samples
Coding Sequence 119 (1.8%)
Protein Affecting 98 (1.4%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all WNK3 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 21 17 4.61
Breast carcinoma No 13 12 1.05
Lung adenocarcinoma No 12 11 2.81
Head and neck squamous cell carcinoma No 12 10 2.67
Lung squamous cell carcinoma No 10 8 4.60
Uterine corpus endometrioid carcinoma No 9 7 3.04
Esophageal carcinoma No 6 6 4.11
Colorectal adenocarcinoma No 7 5 2.18
Bladder carcinoma No 4 4 4.08
Stomach adenocarcinoma No 5 4 2.48
Renal clear cell carcinoma No 3 3 0.72
Serous ovarian adenocarcinoma No 4 3 0.95
Glioblastoma multiforme No 3 2 0.53
Prostate adenocarcinoma No 1 1 0.41
Acute myeloid leukemia No 1 1 0.51
Pancreas adenocarcinoma No 1 1 0.47
Neuroblastoma No 1 1 0.48
Non small cell lung carcinoma No 1 1 3.23
Small cell lung carcinoma No 1 1 1.45
Hepatocarcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 2 0 0.00
Pylocytic astrocytoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence