IntOGen - WNK2 gene cancer mutations

WNK2 is detected as a mutational cancer driver

WNK2 reports

Methods
Mutation distribution

Gene details

WNK2
Ensembl ID ENSG00000165238 Transcript ID ENST00000297954 Protein ID ENSP00000297954
Cancer types where is driver 2 Cohorts where is driver 2 Mutated samples 8 Mutations 820
Mode of action Ambiguous
Known driver True

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence