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WDR6 has not been detected as a mutational cancer driver

WDR6
Ensembl id ENSG00000178252
Mutated samples
Coding Sequence 97 (1.4%)
Protein Affecting 43 (0.6%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all WDR6 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 25 11 2.98
Stomach adenocarcinoma No 10 8 4.97
Lung adenocarcinoma No 9 4 1.02
Uterine corpus endometrioid carcinoma No 4 4 1.74
Bladder carcinoma No 7 3 3.06
Breast carcinoma No 12 3 0.26
Head and neck squamous cell carcinoma No 8 3 0.80
Lung squamous cell carcinoma No 8 2 1.15
Prostate adenocarcinoma No 2 1 0.41
Medulloblastoma No 1 1 0.48
Lower grade glioma No 1 1 0.59
Serous ovarian adenocarcinoma No 2 1 0.32
Colorectal adenocarcinoma No 1 1 0.44
Pancreas adenocarcinoma No 1 0 0.00
Small cell lung carcinoma No 2 0 0.00
Glioblastoma multiforme No 2 0 0.00
Esophageal carcinoma No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence