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WDR49 has not been detected as a mutational cancer driver

WDR49
Ensembl id ENSG00000174776
Mutated samples
Coding Sequence 139 (2.0%)
Protein Affecting 108 (1.6%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all WDR49 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 53 40 10.84
Lung adenocarcinoma No 14 13 3.32
Lung squamous cell carcinoma No 10 8 4.60
Stomach adenocarcinoma No 10 8 4.97
Head and neck squamous cell carcinoma No 7 7 1.87
Bladder carcinoma No 6 5 5.10
Breast carcinoma No 4 4 0.35
Small cell lung carcinoma No 5 4 5.80
Esophageal carcinoma No 7 4 2.74
Prostate adenocarcinoma No 3 3 1.23
Uterine corpus endometrioid carcinoma No 2 2 0.87
Serous ovarian adenocarcinoma No 2 2 0.63
Colorectal adenocarcinoma No 4 2 0.87
Hepatocarcinoma No 3 1 1.11
Pancreas adenocarcinoma No 1 1 0.47
Renal clear cell carcinoma No 1 1 0.24
Thyroid carcinoma No 1 1 0.31
Neuroblastoma No 1 1 0.48
Lower grade glioma No 2 1 0.59
Medulloblastoma No 1 0 0.00
Chronic lymphocytic leukemia No 1 0 0.00
Pylocytic astrocytoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence