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WDR45 has not been detected as a mutational cancer driver

WDR45
Ensembl id ENSG00000196998
Mutated samples
Coding Sequence 33 (0.5%)
Protein Affecting 11 (0.2%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all WDR45 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Uterine corpus endometrioid carcinoma No 5 5 2.17
Breast carcinoma No 4 1 0.09
Medulloblastoma No 2 1 0.48
Lung squamous cell carcinoma No 3 1 0.57
Cutaneous melanoma No 8 1 0.27
Stomach adenocarcinoma No 1 1 0.62
Glioblastoma multiforme No 1 1 0.26
Bladder carcinoma No 1 0 0.00
Neuroblastoma No 1 0 0.00
Non small cell lung carcinoma No 1 0 0.00
Serous ovarian adenocarcinoma No 1 0 0.00
Small cell lung carcinoma No 1 0 0.00
Colorectal adenocarcinoma No 1 0 0.00
Head and neck squamous cell carcinoma No 3 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence