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VPS8 has not been detected as a mutational cancer driver

VPS8
Ensembl id ENSG00000156931
Mutated samples
Coding Sequence 76 (1.1%)
Protein Affecting 55 (0.8%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all VPS8 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 15 9 2.44
Lung squamous cell carcinoma No 8 6 3.45
Uterine corpus endometrioid carcinoma No 6 6 2.61
Breast carcinoma No 6 5 0.44
Head and neck squamous cell carcinoma No 6 5 1.33
Glioblastoma multiforme No 5 5 1.32
Lung adenocarcinoma No 5 4 1.02
Bladder carcinoma No 4 4 4.08
Stomach adenocarcinoma No 4 3 1.86
Pancreas adenocarcinoma No 2 2 0.93
Renal clear cell carcinoma No 2 2 0.48
Colorectal adenocarcinoma No 2 2 0.87
Serous ovarian adenocarcinoma No 1 1 0.32
Esophageal carcinoma No 2 1 0.68
Medulloblastoma No 3 0 0.00
Chronic lymphocytic leukemia No 4 0 0.00
Multiple myeloma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence