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VPS13D has not been detected as a mutational cancer driver

VPS13D
Ensembl id ENSG00000048707
Mutated samples
Coding Sequence 226 (3.3%)
Protein Affecting 160 (2.4%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all VPS13D gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 70 45 12.20
Head and neck squamous cell carcinoma No 22 17 4.53
Lung squamous cell carcinoma No 19 15 8.62
Breast carcinoma No 17 13 1.13
Lung adenocarcinoma No 15 10 2.56
Stomach adenocarcinoma No 15 10 6.21
Uterine corpus endometrioid carcinoma No 10 9 3.91
Bladder carcinoma No 11 8 8.16
Renal clear cell carcinoma No 10 6 1.44
Prostate adenocarcinoma No 4 4 1.65
Serous ovarian adenocarcinoma No 5 3 0.95
Small cell lung carcinoma No 3 3 4.35
Glioblastoma multiforme No 3 3 0.79
Thyroid carcinoma No 2 2 0.62
Neuroblastoma No 2 2 0.95
Lower grade glioma No 3 2 1.18
Colorectal adenocarcinoma No 5 2 0.87
Esophageal carcinoma No 2 2 1.37
Hepatocarcinoma No 2 1 1.11
Acute myeloid leukemia No 1 1 0.51
Pancreas adenocarcinoma No 1 1 0.47
Non small cell lung carcinoma No 2 1 3.23
Medulloblastoma No 1 0 0.00
Chronic lymphocytic leukemia No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence