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USP21 has not been detected as a mutational cancer driver

USP21
Ensembl id ENSG00000143258
Mutated samples
Coding Sequence 68 (1.0%)
Protein Affecting 32 (0.5%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all USP21 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 16 7 1.90
Stomach adenocarcinoma No 10 7 4.35
Uterine corpus endometrioid carcinoma No 7 5 2.17
Breast carcinoma No 5 2 0.17
Lung squamous cell carcinoma No 3 2 1.15
Renal clear cell carcinoma No 2 2 0.48
Serous ovarian adenocarcinoma No 3 2 0.63
Head and neck squamous cell carcinoma No 3 2 0.53
Lung adenocarcinoma No 6 1 0.26
Bladder carcinoma No 2 1 1.02
Multiple myeloma No 1 1 1.45
Hepatocarcinoma No 1 0 0.00
Thyroid carcinoma No 1 0 0.00
Neuroblastoma No 1 0 0.00
Lower grade glioma No 1 0 0.00
Colorectal adenocarcinoma No 2 0 0.00
Glioblastoma multiforme No 1 0 0.00
Esophageal carcinoma No 2 0 0.00
Acute lymphocytic leukemia No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence