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USH2A has not been detected as a mutational cancer driver

USH2A
Ensembl id ENSG00000042781
Mutated samples
Coding Sequence 683 (10.1%)
Protein Affecting 553 (8.1%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all USH2A gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 140 119 32.25
Lung adenocarcinoma No 87 72 18.41
Lung squamous cell carcinoma No 67 64 36.78
Head and neck squamous cell carcinoma No 58 48 12.80
Breast carcinoma No 51 44 3.83
Stomach adenocarcinoma No 39 32 19.88
Small cell lung carcinoma No 26 23 33.33
Uterine corpus endometrioid carcinoma No 26 20 8.70
Serous ovarian adenocarcinoma No 23 20 6.33
Esophageal carcinoma No 26 20 13.70
Renal clear cell carcinoma No 20 17 4.08
Glioblastoma multiforme No 23 16 4.22
Colorectal adenocarcinoma No 17 12 5.24
Bladder carcinoma No 12 10 10.20
Prostate adenocarcinoma No 9 8 3.29
Hepatocarcinoma No 10 7 7.78
Non small cell lung carcinoma No 8 5 16.13
Neuroblastoma No 5 4 1.90
Chronic lymphocytic leukemia No 21 3 1.03
Multiple myeloma No 3 3 4.35
Lower grade glioma No 4 2 1.18
Medulloblastoma No 2 1 0.48
Pancreas adenocarcinoma No 1 1 0.47
Thyroid carcinoma No 2 1 0.31
Diffuse B cell lymphoma No 1 1 4.35
Pylocytic astrocytoma No 1 0 0.00
Acute lymphocytic leukemia No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence