Top
UPF3B mutations in 2 cancer types possibly contribute to the detection of the gene in the PAN-cancer anlaysis:: Lung adenocarcinoma, Lung squamous cell carcinoma

UPF3B
Ensembl id ENSG00000125351
Mutated samples
Coding Sequence 40 (0.6%)
Protein Affecting 36 (0.5%)
Mode of action Loss of function
Known driver No
Cancer type Signals (Biases)
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all UPF3B gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Lung adenocarcinoma Yes 4 4 1.02
Lung squamous cell carcinoma Yes 5 4 2.30
Cutaneous melanoma No 9 8 2.17
Uterine corpus endometrioid carcinoma No 5 5 2.17
Breast carcinoma No 5 4 0.35
Head and neck squamous cell carcinoma No 2 2 0.53
Hepatocarcinoma No 1 1 1.11
Bladder carcinoma No 1 1 1.02
Medulloblastoma No 1 1 0.48
Renal clear cell carcinoma No 1 1 0.24
Non small cell lung carcinoma No 1 1 3.23
Serous ovarian adenocarcinoma No 1 1 0.32
Stomach adenocarcinoma No 1 1 0.62
Colorectal adenocarcinoma No 1 1 0.44
Glioblastoma multiforme No 1 1 0.26
Chronic lymphocytic leukemia No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence