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UGT1A9 has not been detected as a mutational cancer driver

UGT1A9
Ensembl id ENSG00000241119
Mutated samples
Coding Sequence 237 (3.5%)
Protein Affecting 52 (0.8%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all UGT1A9 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 91 24 6.50
Lung adenocarcinoma No 20 5 1.28
Lung squamous cell carcinoma No 15 5 2.87
Bladder carcinoma No 9 3 3.06
Breast carcinoma No 18 3 0.26
Uterine corpus endometrioid carcinoma No 7 2 0.87
Serous ovarian adenocarcinoma No 7 2 0.63
Colorectal adenocarcinoma No 4 2 0.87
Head and neck squamous cell carcinoma No 12 2 0.53
Non small cell lung carcinoma No 1 1 3.23
Lower grade glioma No 7 1 0.59
Stomach adenocarcinoma No 9 1 0.62
Glioblastoma multiforme No 11 1 0.26
Prostate adenocarcinoma No 1 0 0.00
Hepatocarcinoma No 4 0 0.00
Medulloblastoma No 1 0 0.00
Renal clear cell carcinoma No 5 0 0.00
Thyroid carcinoma No 1 0 0.00
Neuroblastoma No 2 0 0.00
Chronic lymphocytic leukemia No 2 0 0.00
Multiple myeloma No 1 0 0.00
Pylocytic astrocytoma No 1 0 0.00
Small cell lung carcinoma No 1 0 0.00
Esophageal carcinoma No 7 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence