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UGT1A8 has not been detected as a mutational cancer driver

UGT1A8
Ensembl id ENSG00000242366
Mutated samples
Coding Sequence 290 (4.3%)
Protein Affecting 51 (0.8%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all UGT1A8 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 106 19 5.15
Lung squamous cell carcinoma No 21 5 2.87
Breast carcinoma No 23 4 0.35
Prostate adenocarcinoma No 4 3 1.23
Lung adenocarcinoma No 24 3 0.77
Uterine corpus endometrioid carcinoma No 10 3 1.30
Head and neck squamous cell carcinoma No 17 3 0.80
Renal clear cell carcinoma No 7 2 0.48
Non small cell lung carcinoma No 2 2 6.45
Serous ovarian adenocarcinoma No 11 2 0.63
Bladder carcinoma No 9 1 1.02
Lower grade glioma No 7 1 0.59
Stomach adenocarcinoma No 9 1 0.62
Colorectal adenocarcinoma No 4 1 0.44
Glioblastoma multiforme No 14 1 0.26
Hepatocarcinoma No 5 0 0.00
Acute myeloid leukemia No 1 0 0.00
Medulloblastoma No 1 0 0.00
Thyroid carcinoma No 1 0 0.00
Neuroblastoma No 2 0 0.00
Chronic lymphocytic leukemia No 2 0 0.00
Multiple myeloma No 1 0 0.00
Pylocytic astrocytoma No 1 0 0.00
Small cell lung carcinoma No 1 0 0.00
Esophageal carcinoma No 7 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence