Top
UGT1A6 has not been detected as a mutational cancer driver

UGT1A6
Ensembl id ENSG00000167165
Mutated samples
Coding Sequence 192 (2.8%)
Protein Affecting 41 (0.6%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all UGT1A6 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 76 15 4.07
Lung adenocarcinoma No 16 5 1.28
Breast carcinoma No 16 4 0.35
Bladder carcinoma No 8 2 2.04
Lung squamous cell carcinoma No 10 2 1.15
Uterine corpus endometrioid carcinoma No 6 2 0.87
Head and neck squamous cell carcinoma No 9 2 0.53
Glioblastoma multiforme No 9 2 0.53
Renal clear cell carcinoma No 3 1 0.24
Neuroblastoma No 2 1 0.48
Non small cell lung carcinoma No 1 1 3.23
Lower grade glioma No 6 1 0.59
Stomach adenocarcinoma No 8 1 0.62
Small cell lung carcinoma No 1 1 1.45
Colorectal adenocarcinoma No 3 1 0.44
Hepatocarcinoma No 4 0 0.00
Medulloblastoma No 1 0 0.00
Thyroid carcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 2 0 0.00
Multiple myeloma No 1 0 0.00
Serous ovarian adenocarcinoma No 3 0 0.00
Pylocytic astrocytoma No 1 0 0.00
Esophageal carcinoma No 5 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence