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UGT1A4 has not been detected as a mutational cancer driver

UGT1A4
Ensembl id ENSG00000244474
Mutated samples
Coding Sequence 155 (2.3%)
Protein Affecting 41 (0.6%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all UGT1A4 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 68 20 5.42
Breast carcinoma No 13 4 0.35
Lung squamous cell carcinoma No 7 3 1.72
Colorectal adenocarcinoma No 3 3 1.31
Lung adenocarcinoma No 13 2 0.51
Renal clear cell carcinoma No 2 2 0.48
Uterine corpus endometrioid carcinoma No 6 2 0.87
Bladder carcinoma No 6 1 1.02
Non small cell lung carcinoma No 1 1 3.23
Lower grade glioma No 4 1 0.59
Stomach adenocarcinoma No 7 1 0.62
Head and neck squamous cell carcinoma No 6 1 0.27
Hepatocarcinoma No 3 0 0.00
Medulloblastoma No 1 0 0.00
Thyroid carcinoma No 1 0 0.00
Neuroblastoma No 1 0 0.00
Chronic lymphocytic leukemia No 1 0 0.00
Serous ovarian adenocarcinoma No 2 0 0.00
Glioblastoma multiforme No 6 0 0.00
Esophageal carcinoma No 4 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence