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UGT1A10 has not been detected as a mutational cancer driver

UGT1A10
Ensembl id ENSG00000242515
Mutated samples
Coding Sequence 262 (3.9%)
Protein Affecting 47 (0.7%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all UGT1A10 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 98 19 5.15
Lung adenocarcinoma No 23 5 1.28
Breast carcinoma No 20 4 0.35
Lung squamous cell carcinoma No 18 4 2.30
Uterine corpus endometrioid carcinoma No 9 3 1.30
Head and neck squamous cell carcinoma No 14 3 0.80
Serous ovarian adenocarcinoma No 9 2 0.63
Bladder carcinoma No 9 1 1.02
Acute myeloid leukemia No 1 1 0.51
Non small cell lung carcinoma No 1 1 3.23
Lower grade glioma No 7 1 0.59
Stomach adenocarcinoma No 9 1 0.62
Colorectal adenocarcinoma No 4 1 0.44
Glioblastoma multiforme No 13 1 0.26
Prostate adenocarcinoma No 1 0 0.00
Hepatocarcinoma No 5 0 0.00
Medulloblastoma No 1 0 0.00
Renal clear cell carcinoma No 5 0 0.00
Thyroid carcinoma No 1 0 0.00
Neuroblastoma No 2 0 0.00
Chronic lymphocytic leukemia No 2 0 0.00
Multiple myeloma No 1 0 0.00
Pylocytic astrocytoma No 1 0 0.00
Small cell lung carcinoma No 1 0 0.00
Esophageal carcinoma No 7 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence