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UBR3 has not been detected as a mutational cancer driver

UBR3
Ensembl id ENSG00000144357
Mutated samples
Coding Sequence 65 (1.0%)
Protein Affecting 48 (0.7%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all UBR3 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 8 7 1.90
Breast carcinoma No 6 6 0.52
Uterine corpus endometrioid carcinoma No 5 5 2.17
Stomach adenocarcinoma No 7 4 2.48
Lung adenocarcinoma No 3 3 0.77
Hepatocarcinoma No 7 3 3.33
Head and neck squamous cell carcinoma No 3 3 0.80
Prostate adenocarcinoma No 2 2 0.82
Renal clear cell carcinoma No 3 2 0.48
Lower grade glioma No 2 2 1.18
Small cell lung carcinoma No 3 2 2.90
Medulloblastoma No 1 1 0.48
Lung squamous cell carcinoma No 2 1 0.57
Thyroid carcinoma No 1 1 0.31
Non small cell lung carcinoma No 1 1 3.23
Multiple myeloma No 1 1 1.45
Serous ovarian adenocarcinoma No 1 1 0.32
Colorectal adenocarcinoma No 1 1 0.44
Glioblastoma multiforme No 2 1 0.26
Esophageal carcinoma No 1 1 0.68
Bladder carcinoma No 2 0 0.00
Acute myeloid leukemia No 1 0 0.00
Chronic lymphocytic leukemia No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence