TXNIP is detected as a mutational cancer driver in 1 cancer type: Bladder carcinoma

Ensembl id ENSG00000117289
Mutated samples
Coding Sequence 46 (0.7%)
Protein Affecting 24 (0.4%)
Mode of action Activating
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all TXNIP gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Bladder carcinoma Yes 5 5 5.10
Breast carcinoma No 8 5 0.44
Renal clear cell carcinoma No 5 4 0.96
Prostate adenocarcinoma No 3 2 0.82
Cutaneous melanoma No 4 2 0.54
Head and neck squamous cell carcinoma No 2 2 0.53
Lung adenocarcinoma No 3 1 0.26
Uterine corpus endometrioid carcinoma No 3 1 0.43
Serous ovarian adenocarcinoma No 2 1 0.32
Glioblastoma multiforme No 4 1 0.26
Non small cell lung carcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 1 0 0.00
Multiple myeloma No 1 0 0.00
Stomach adenocarcinoma No 4 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence