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TTC21B has not been detected as a mutational cancer driver

TTC21B
Ensembl id ENSG00000123607
Mutated samples
Coding Sequence 88 (1.3%)
Protein Affecting 70 (1.0%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all TTC21B gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 15 12 3.25
Lung squamous cell carcinoma No 10 9 5.17
Lung adenocarcinoma No 11 8 2.05
Uterine corpus endometrioid carcinoma No 8 7 3.04
Breast carcinoma No 6 6 0.52
Stomach adenocarcinoma No 7 6 3.73
Small cell lung carcinoma No 3 3 4.35
Head and neck squamous cell carcinoma No 3 3 0.80
Hepatocarcinoma No 5 2 2.22
Bladder carcinoma No 2 2 2.04
Renal clear cell carcinoma No 2 2 0.48
Serous ovarian adenocarcinoma No 2 2 0.63
Colorectal adenocarcinoma No 2 2 0.87
Esophageal carcinoma No 3 2 1.37
Thyroid carcinoma No 1 1 0.31
Chronic lymphocytic leukemia No 3 1 0.34
Multiple myeloma No 1 1 1.45
Glioblastoma multiforme No 1 1 0.26
Medulloblastoma No 1 0 0.00
Pancreas adenocarcinoma No 1 0 0.00
Non small cell lung carcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence