TSC1 is detected as a mutational cancer driver in 1 Bladder carcinoma project

Bladder carcinoma
Projects 1
98 Samples
Coding sequence mutations (CSMs)
in driver genes 954
in all genes 42075
Protein affecting mutations (PAMs)
in driver genes 816
in all genes 20707
Ensembl id ENSG00000165699
Mutated samples
Coding Sequence 6 (6.1%)
Protein Affecting 6 (6.1%)
Mode of action Loss of function
Known driver Yes
Project Signals
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated Bladder carcinoma projects in all TSC1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Project Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Bladder urothelial carcinoma TCGA Yes 6 6 6.12
The mutations needle plot shows the distribution of the observed TSC1 cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence Driver classification