Top
TRPM8 has not been detected as a mutational cancer driver

TRPM8
Ensembl id ENSG00000144481
Mutated samples
Coding Sequence 88 (1.3%)
Protein Affecting 61 (0.9%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all TRPM8 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 32 21 5.69
Lung adenocarcinoma No 13 10 2.56
Breast carcinoma No 9 9 0.78
Lung squamous cell carcinoma No 6 4 2.30
Uterine corpus endometrioid carcinoma No 4 3 1.30
Small cell lung carcinoma No 4 3 4.35
Hepatocarcinoma No 3 2 2.22
Acute myeloid leukemia No 1 1 0.51
Non small cell lung carcinoma No 2 1 3.23
Lower grade glioma No 1 1 0.59
Serous ovarian adenocarcinoma No 1 1 0.32
Stomach adenocarcinoma No 1 1 0.62
Colorectal adenocarcinoma No 1 1 0.44
Head and neck squamous cell carcinoma No 3 1 0.27
Glioblastoma multiforme No 4 1 0.26
Esophageal carcinoma No 1 1 0.68
Chronic lymphocytic leukemia No 1 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence