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TRIP12 has not been detected as a mutational cancer driver

TRIP12
Ensembl id ENSG00000153827
Mutated samples
Coding Sequence 135 (2.0%)
Protein Affecting 104 (1.5%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all TRIP12 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 22 18 4.88
Lung adenocarcinoma No 12 11 2.81
Breast carcinoma No 12 10 0.87
Head and neck squamous cell carcinoma No 11 10 2.67
Lung squamous cell carcinoma No 10 9 5.17
Stomach adenocarcinoma No 11 9 5.59
Esophageal carcinoma No 8 6 4.11
Uterine corpus endometrioid carcinoma No 4 4 1.74
Serous ovarian adenocarcinoma No 5 4 1.27
Renal clear cell carcinoma No 4 3 0.72
Lower grade glioma No 3 3 1.78
Small cell lung carcinoma No 3 3 4.35
Prostate adenocarcinoma No 2 2 0.82
Bladder carcinoma No 6 2 2.04
Multiple myeloma No 2 2 2.90
Colorectal adenocarcinoma No 3 2 0.87
Hepatocarcinoma No 2 1 1.11
Pancreas adenocarcinoma No 1 1 0.47
Thyroid carcinoma No 1 1 0.31
Non small cell lung carcinoma No 2 1 3.23
Chronic lymphocytic leukemia No 6 1 0.34
Glioblastoma multiforme No 4 1 0.26
Medulloblastoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence