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TRIM42 has not been detected as a mutational cancer driver

TRIM42
Ensembl id ENSG00000155890
Mutated samples
Coding Sequence 107 (1.6%)
Protein Affecting 80 (1.2%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all TRIM42 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 30 21 5.69
Lung adenocarcinoma No 13 10 2.56
Lung squamous cell carcinoma No 9 7 4.02
Breast carcinoma No 7 6 0.52
Head and neck squamous cell carcinoma No 6 6 1.60
Stomach adenocarcinoma No 5 4 2.48
Bladder carcinoma No 3 3 3.06
Small cell lung carcinoma No 5 3 4.35
Colorectal adenocarcinoma No 5 3 1.31
Glioblastoma multiforme No 3 3 0.79
Prostate adenocarcinoma No 2 2 0.82
Uterine corpus endometrioid carcinoma No 3 2 0.87
Serous ovarian adenocarcinoma No 2 2 0.63
Esophageal carcinoma No 4 2 1.37
Pancreas adenocarcinoma No 1 1 0.47
Renal clear cell carcinoma No 2 1 0.24
Neuroblastoma No 1 1 0.48
Non small cell lung carcinoma No 2 1 3.23
Chronic lymphocytic leukemia No 3 1 0.34
Acute lymphocytic leukemia No 1 1 0.82
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence