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TRANK1 has not been detected as a mutational cancer driver

TRANK1
Ensembl id ENSG00000168016
Mutated samples
Coding Sequence 167 (2.5%)
Protein Affecting 126 (1.9%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all TRANK1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 84 66 17.89
Breast carcinoma No 11 8 0.70
Uterine corpus endometrioid carcinoma No 7 7 3.04
Stomach adenocarcinoma No 8 7 4.35
Lung squamous cell carcinoma No 9 6 3.45
Head and neck squamous cell carcinoma No 11 6 1.60
Lung adenocarcinoma No 5 5 1.28
Bladder carcinoma No 8 5 5.10
Renal clear cell carcinoma No 4 3 0.72
Thyroid carcinoma No 2 2 0.62
Chronic lymphocytic leukemia No 2 2 0.69
Colorectal adenocarcinoma No 3 2 0.87
Esophageal carcinoma No 2 2 1.37
Prostate adenocarcinoma No 3 1 0.41
Hepatocarcinoma No 2 1 1.11
Multiple myeloma No 1 1 1.45
Serous ovarian adenocarcinoma No 1 1 0.32
Glioblastoma multiforme No 3 1 0.26
Pancreas adenocarcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence