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TRAF5 has not been detected as a mutational cancer driver

TRAF5
Ensembl id ENSG00000082512
Mutated samples
Coding Sequence 38 (0.6%)
Protein Affecting 23 (0.3%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all TRAF5 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 12 7 1.90
Renal clear cell carcinoma No 4 3 0.72
Breast carcinoma No 2 2 0.17
Lung squamous cell carcinoma No 2 2 1.15
Uterine corpus endometrioid carcinoma No 2 2 0.87
Head and neck squamous cell carcinoma No 3 2 0.53
Prostate adenocarcinoma No 1 1 0.41
Lung adenocarcinoma No 1 1 0.26
Serous ovarian adenocarcinoma No 1 1 0.32
Stomach adenocarcinoma No 3 1 0.62
Colorectal adenocarcinoma No 2 1 0.44
Bladder carcinoma No 1 0 0.00
Medulloblastoma No 1 0 0.00
Chronic lymphocytic leukemia No 1 0 0.00
Small cell lung carcinoma No 1 0 0.00
Esophageal carcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence