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TPR has not been detected as a mutational cancer driver

TPR
Ensembl id ENSG00000047410
Mutated samples
Coding Sequence 173 (2.5%)
Protein Affecting 114 (1.7%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all TPR gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 34 16 4.34
Lung squamous cell carcinoma No 19 15 8.62
Breast carcinoma No 16 13 1.13
Lung adenocarcinoma No 15 12 3.07
Uterine corpus endometrioid carcinoma No 10 9 3.91
Stomach adenocarcinoma No 18 9 5.59
Bladder carcinoma No 11 7 7.14
Head and neck squamous cell carcinoma No 6 6 1.60
Small cell lung carcinoma No 4 4 5.80
Medulloblastoma No 3 3 1.43
Glioblastoma multiforme No 5 3 0.79
Prostate adenocarcinoma No 2 2 0.82
Renal clear cell carcinoma No 7 2 0.48
Non small cell lung carcinoma No 4 2 6.45
Multiple myeloma No 2 2 2.90
Lower grade glioma No 3 2 1.18
Colorectal adenocarcinoma No 2 2 0.87
Esophageal carcinoma No 4 2 1.37
Hepatocarcinoma No 2 1 1.11
Neuroblastoma No 1 1 0.48
Serous ovarian adenocarcinoma No 2 1 0.32
Chronic lymphocytic leukemia No 1 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
Acute lymphocytic leukemia No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence