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TPM3 has not been detected as a mutational cancer driver

TPM3
Ensembl id ENSG00000143549
Mutated samples
Coding Sequence 37 (0.5%)
Protein Affecting 15 (0.2%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all TPM3 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Breast carcinoma No 7 4 0.35
Cutaneous melanoma No 10 3 0.81
Lung adenocarcinoma No 3 1 0.26
Lung squamous cell carcinoma No 1 1 0.57
Thyroid carcinoma No 1 1 0.31
Uterine corpus endometrioid carcinoma No 3 1 0.43
Lower grade glioma No 1 1 0.59
Head and neck squamous cell carcinoma No 2 1 0.27
Glioblastoma multiforme No 2 1 0.26
Esophageal carcinoma No 1 1 0.68
Hepatocarcinoma No 1 0 0.00
Bladder carcinoma No 2 0 0.00
Chronic lymphocytic leukemia No 2 0 0.00
Stomach adenocarcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence