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TP73 has not been detected as a mutational cancer driver

TP73
Ensembl id ENSG00000078900
Mutated samples
Coding Sequence 44 (0.6%)
Protein Affecting 33 (0.5%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all TP73 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 7 6 1.63
Lung adenocarcinoma No 5 5 1.28
Uterine corpus endometrioid carcinoma No 6 5 2.17
Renal clear cell carcinoma No 4 3 0.72
Small cell lung carcinoma No 3 3 4.35
Breast carcinoma No 3 2 0.17
Thyroid carcinoma No 2 2 0.62
Stomach adenocarcinoma No 4 2 1.24
Bladder carcinoma No 3 1 1.02
Acute myeloid leukemia No 1 1 0.51
Non small cell lung carcinoma No 2 1 3.23
Serous ovarian adenocarcinoma No 1 1 0.32
Diffuse B cell lymphoma No 1 1 4.35
Chronic lymphocytic leukemia No 1 0 0.00
Pylocytic astrocytoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence