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TP53 is detected as a mutational cancer driver in 1 Uterine corpus endometrioid carcinoma project

Uterine corpus endometrioid carcinoma
Projects 1
230 Samples
Coding sequence mutations (CSMs)
in driver genes 1784
in all genes 68806
Protein affecting mutations (PAMs)
in driver genes 1591
in all genes 34136
TP53
Ensembl id ENSG00000141510
Mutated samples
Coding Sequence 66 (28.7%)
Protein Affecting 61 (26.5%)
Mode of action Loss of function
Known driver Yes
Project Signals
UCEC_TCGA RF
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated Uterine corpus endometrioid carcinoma projects in all TP53 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Project Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Uterine corpus endometrioid carcinoma TCGA Yes 66 61 26.52
The mutations needle plot shows the distribution of the observed TP53 cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence Driver classification