TP53 is detected as a mutational cancer driver in 2 Stomach adenocarcinoma projects

Stomach adenocarcinoma
Projects 2
161 Samples
Coding sequence mutations (CSMs)
in driver genes 1061
in all genes 79369
Protein affecting mutations (PAMs)
in driver genes 869
in all genes 37552
Ensembl id ENSG00000141510
Mutated samples
Coding Sequence 72 (44.7%)
Protein Affecting 71 (44.1%)
Mode of action Loss of function
Known driver Yes
Project Signals
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated Stomach adenocarcinoma projects in all TP53 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Project Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Stomach cancer TCGA obtained from Synapse Yes 63 62 38.51
Gastric cancer Pfizer Yes 9 9 5.59
The mutations needle plot shows the distribution of the observed TP53 cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence Driver classification