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TP53 is detected as a mutational cancer driver in 1 Multiple myeloma project

Multiple myeloma
Projects 1
69 Samples
Coding sequence mutations (CSMs)
in driver genes 97
in all genes 5450
Protein affecting mutations (PAMs)
in driver genes 92
in all genes 2614
TP53
Ensembl id ENSG00000141510
Mutated samples
Coding Sequence 10 (14.5%)
Protein Affecting 10 (14.5%)
Mode of action Loss of function
Known driver Yes
Project Signals
MM_SANGER F
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated Multiple myeloma projects in all TP53 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Project Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Myeloma New Samples obtained from AlexandrovEtAl Yes 10 10 14.49
The mutations needle plot shows the distribution of the observed TP53 cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence Driver classification