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TP53 is detected as a mutational cancer driver in 2 Lung adenocarcinoma projects

Lung adenocarcinoma
Projects 2
391 Samples
Coding sequence mutations (CSMs)
in driver genes 1564
in all genes 112729
Protein affecting mutations (PAMs)
in driver genes 1381
in all genes 61402
TP53
Ensembl id ENSG00000141510
Mutated samples
Coding Sequence 184 (47.1%)
Protein Affecting 183 (46.8%)
Mode of action Loss of function
Known driver Yes
Project Signals
LUAD_WUSTL F
LUAD_TCGA RF
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated Lung adenocarcinoma projects in all TP53 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Project Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Lung adenocarcinoma TCGA Yes 120 120 30.69
Lung adenocarcinoma Washington University Yes 64 63 16.11
The mutations needle plot shows the distribution of the observed TP53 cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence Driver classification