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TP53 is detected as a mutational cancer driver in 1 Diffuse B cell lymphoma project

Diffuse B cell lymphoma
Projects 1
23 Samples
Coding sequence mutations (CSMs)
in driver genes 74
in all genes 6097
Protein affecting mutations (PAMs)
in driver genes 52
in all genes 1034
TP53
Ensembl id ENSG00000141510
Mutated samples
Coding Sequence 6 (26.1%)
Protein Affecting 6 (26.1%)
Mode of action Loss of function
Known driver Yes
Project Signals
DLBC_SANGER F
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated Diffuse B cell lymphoma projects in all TP53 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Project Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Difuse B cell lymphoma obtained from AlexandrovEtAl Yes 6 6 26.09
The mutations needle plot shows the distribution of the observed TP53 cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence Driver classification