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TP53 is detected as a mutational cancer driver in 2 Chronic lymphocytic leukemia projects

Chronic lymphocytic leukemia
Projects 2
290 Samples
Coding sequence mutations (CSMs)
in driver genes 280
in all genes 49201
Protein affecting mutations (PAMs)
in driver genes 213
in all genes 4046
TP53
Ensembl id ENSG00000141510
Mutated samples
Coding Sequence 26 (9.0%)
Protein Affecting 25 (8.6%)
Mode of action Loss of function
Known driver Yes
Project Signals
CLL_DFCI FC
CLL_ISCIII F
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated Chronic lymphocytic leukemia projects in all TP53 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Project Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Chronic Lymphocytic Leukemia Broad Yes 19 18 6.21
Chronic Lymphocytic Leukemia Spain Yes 7 7 2.41
The mutations needle plot shows the distribution of the observed TP53 cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence Driver classification