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TOPBP1 has not been detected as a mutational cancer driver

TOPBP1
Ensembl id ENSG00000163781
Mutated samples
Coding Sequence 71 (1.0%)
Protein Affecting 59 (0.9%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all TOPBP1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Breast carcinoma No 8 7 0.61
Cutaneous melanoma No 10 7 1.90
Head and neck squamous cell carcinoma No 7 6 1.60
Bladder carcinoma No 7 5 5.10
Lung squamous cell carcinoma No 6 5 2.87
Uterine corpus endometrioid carcinoma No 6 5 2.17
Stomach adenocarcinoma No 6 5 3.11
Renal clear cell carcinoma No 4 4 0.96
Lung adenocarcinoma No 4 3 0.77
Esophageal carcinoma No 3 3 2.05
Thyroid carcinoma No 2 2 0.62
Neuroblastoma No 2 2 0.95
Serous ovarian adenocarcinoma No 2 2 0.63
Prostate adenocarcinoma No 1 1 0.41
Chronic lymphocytic leukemia No 1 1 0.34
Small cell lung carcinoma No 1 1 1.45
Hepatocarcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence