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TNR has not been detected as a mutational cancer driver

TNR
Ensembl id ENSG00000116147
Mutated samples
Coding Sequence 262 (3.9%)
Protein Affecting 187 (2.8%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all TNR gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 81 59 15.99
Lung adenocarcinoma No 42 31 7.93
Lung squamous cell carcinoma No 30 23 13.22
Breast carcinoma No 16 11 0.96
Renal clear cell carcinoma No 11 8 1.92
Stomach adenocarcinoma No 11 7 4.35
Small cell lung carcinoma No 8 7 10.14
Uterine corpus endometrioid carcinoma No 7 6 2.61
Colorectal adenocarcinoma No 7 6 2.62
Head and neck squamous cell carcinoma No 11 6 1.60
Bladder carcinoma No 4 4 4.08
Pancreas adenocarcinoma No 5 4 1.87
Esophageal carcinoma No 5 4 2.74
Thyroid carcinoma No 3 3 0.93
Multiple myeloma No 2 2 2.90
Serous ovarian adenocarcinoma No 3 2 0.63
Hepatocarcinoma No 1 1 1.11
Non small cell lung carcinoma No 1 1 3.23
Lower grade glioma No 1 1 0.59
Glioblastoma multiforme No 2 1 0.26
Chronic lymphocytic leukemia No 8 0 0.00
Pylocytic astrocytoma No 2 0 0.00
Acute lymphocytic leukemia No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence