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TNIK has not been detected as a mutational cancer driver

TNIK
Ensembl id ENSG00000154310
Mutated samples
Coding Sequence 120 (1.8%)
Protein Affecting 87 (1.3%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all TNIK gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 35 24 6.50
Lung squamous cell carcinoma No 14 11 6.32
Head and neck squamous cell carcinoma No 18 11 2.93
Lung adenocarcinoma No 8 7 1.79
Uterine corpus endometrioid carcinoma No 7 5 2.17
Serous ovarian adenocarcinoma No 5 5 1.58
Stomach adenocarcinoma No 5 4 2.48
Renal clear cell carcinoma No 3 3 0.72
Multiple myeloma No 3 3 4.35
Breast carcinoma No 6 2 0.17
Chronic lymphocytic leukemia No 5 2 0.69
Colorectal adenocarcinoma No 2 2 0.87
Glioblastoma multiforme No 2 2 0.53
Prostate adenocarcinoma No 1 1 0.41
Hepatocarcinoma No 1 1 1.11
Pancreas adenocarcinoma No 1 1 0.47
Thyroid carcinoma No 1 1 0.31
Neuroblastoma No 1 1 0.48
Small cell lung carcinoma No 1 1 1.45
Bladder carcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence