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TKTL1 has not been detected as a mutational cancer driver

TKTL1
Ensembl id ENSG00000007350
Mutated samples
Coding Sequence 51 (0.8%)
Protein Affecting 34 (0.5%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all TKTL1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Lung adenocarcinoma No 9 8 2.05
Uterine corpus endometrioid carcinoma No 6 5 2.17
Serous ovarian adenocarcinoma No 5 5 1.58
Cutaneous melanoma No 11 3 0.81
Bladder carcinoma No 2 2 2.04
Breast carcinoma No 3 2 0.17
Hepatocarcinoma No 1 1 1.11
Medulloblastoma No 1 1 0.48
Lung squamous cell carcinoma No 1 1 0.57
Renal clear cell carcinoma No 1 1 0.24
Neuroblastoma No 1 1 0.48
Stomach adenocarcinoma No 4 1 0.62
Colorectal adenocarcinoma No 1 1 0.44
Head and neck squamous cell carcinoma No 2 1 0.27
Glioblastoma multiforme No 1 1 0.26
Acute myeloid leukemia No 1 0 0.00
Esophageal carcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence