Top
TIE1 has not been detected as a mutational cancer driver

TIE1
Ensembl id ENSG00000066056
Mutated samples
Coding Sequence 121 (1.8%)
Protein Affecting 76 (1.1%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all TIE1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 50 31 8.40
Stomach adenocarcinoma No 12 8 4.97
Lung adenocarcinoma No 11 7 1.79
Lung squamous cell carcinoma No 10 7 4.02
Prostate adenocarcinoma No 4 3 1.23
Breast carcinoma No 4 3 0.26
Head and neck squamous cell carcinoma No 5 3 0.80
Glioblastoma multiforme No 4 3 0.79
Renal clear cell carcinoma No 3 2 0.48
Uterine corpus endometrioid carcinoma No 5 2 0.87
Serous ovarian adenocarcinoma No 3 2 0.63
Small cell lung carcinoma No 2 2 2.90
Bladder carcinoma No 2 1 1.02
Chronic lymphocytic leukemia No 2 1 0.34
Multiple myeloma No 2 1 1.45
Thyroid carcinoma No 1 0 0.00
Esophageal carcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence