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THSD7B has not been detected as a mutational cancer driver

THSD7B
Ensembl id ENSG00000144229
Mutated samples
Coding Sequence 311 (4.6%)
Protein Affecting 239 (3.5%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all THSD7B gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 120 102 27.64
Lung adenocarcinoma No 25 19 4.86
Lung squamous cell carcinoma No 21 17 9.77
Head and neck squamous cell carcinoma No 21 17 4.53
Esophageal carcinoma No 16 14 9.59
Breast carcinoma No 16 12 1.05
Stomach adenocarcinoma No 14 12 7.45
Glioblastoma multiforme No 12 10 2.64
Renal clear cell carcinoma No 9 9 2.16
Lower grade glioma No 4 4 2.37
Serous ovarian adenocarcinoma No 4 4 1.27
Colorectal adenocarcinoma No 5 4 1.75
Bladder carcinoma No 6 3 3.06
Pancreas adenocarcinoma No 3 3 1.40
Uterine corpus endometrioid carcinoma No 3 2 0.87
Multiple myeloma No 2 2 2.90
Prostate adenocarcinoma No 3 1 0.41
Hepatocarcinoma No 2 1 1.11
Medulloblastoma No 1 1 0.48
Thyroid carcinoma No 1 1 0.31
Small cell lung carcinoma No 1 1 1.45
Chronic lymphocytic leukemia No 17 0 0.00
Pylocytic astrocytoma No 5 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence