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THOC2 has not been detected as a mutational cancer driver

THOC2
Ensembl id ENSG00000125676
Mutated samples
Coding Sequence 124 (1.8%)
Protein Affecting 98 (1.4%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all THOC2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 33 27 7.32
Head and neck squamous cell carcinoma No 17 15 4.00
Uterine corpus endometrioid carcinoma No 12 11 4.78
Lung adenocarcinoma No 9 8 2.05
Lung squamous cell carcinoma No 10 7 4.02
Breast carcinoma No 7 6 0.52
Stomach adenocarcinoma No 7 6 3.73
Glioblastoma multiforme No 6 4 1.06
Serous ovarian adenocarcinoma No 3 3 0.95
Bladder carcinoma No 3 2 2.04
Renal clear cell carcinoma No 2 2 0.48
Lower grade glioma No 2 2 1.18
Small cell lung carcinoma No 2 2 2.90
Colorectal adenocarcinoma No 3 2 0.87
Thyroid carcinoma No 1 1 0.31
Medulloblastoma No 1 0 0.00
Chronic lymphocytic leukemia No 4 0 0.00
Pylocytic astrocytoma No 1 0 0.00
Esophageal carcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence