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TFPI has not been detected as a mutational cancer driver

TFPI
Ensembl id ENSG00000003436
Mutated samples
Coding Sequence 40 (0.6%)
Protein Affecting 23 (0.3%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all TFPI gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 15 11 2.98
Breast carcinoma No 2 2 0.17
Uterine corpus endometrioid carcinoma No 3 2 0.87
Stomach adenocarcinoma No 2 2 1.24
Head and neck squamous cell carcinoma No 2 2 0.53
Lung adenocarcinoma No 1 1 0.26
Renal clear cell carcinoma No 1 1 0.24
Colorectal adenocarcinoma No 2 1 0.44
Diffuse B cell lymphoma No 2 1 4.35
Hepatocarcinoma No 2 0 0.00
Lung squamous cell carcinoma No 1 0 0.00
Thyroid carcinoma No 1 0 0.00
Non small cell lung carcinoma No 2 0 0.00
Chronic lymphocytic leukemia No 2 0 0.00
Lower grade glioma No 1 0 0.00
Acute lymphocytic leukemia No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence