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TET2 is detected as a mutational cancer driver in 1 cancer type: Acute myeloid leukemia

TET2
Ensembl id ENSG00000168769
Mutated samples
Coding Sequence 99 (1.5%)
Protein Affecting 77 (1.1%)
Mode of action Loss of function
Known driver Yes
Cancer type Signals (Biases)
AML FR
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all TET2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Acute myeloid leukemia Yes 17 17 8.67
Cutaneous melanoma No 18 13 3.52
Renal clear cell carcinoma No 9 8 1.92
Lung adenocarcinoma No 8 7 1.79
Breast carcinoma No 7 6 0.52
Uterine corpus endometrioid carcinoma No 8 5 2.17
Lung squamous cell carcinoma No 5 4 2.30
Stomach adenocarcinoma No 4 4 2.48
Bladder carcinoma No 4 3 3.06
Small cell lung carcinoma No 2 2 2.90
Head and neck squamous cell carcinoma No 4 2 0.53
Glioblastoma multiforme No 2 2 0.53
Hepatocarcinoma No 3 1 1.11
Neuroblastoma No 1 1 0.48
Chronic lymphocytic leukemia No 1 1 0.34
Lower grade glioma No 1 1 0.59
Medulloblastoma No 1 0 0.00
Pancreas adenocarcinoma No 1 0 0.00
Multiple myeloma No 1 0 0.00
Colorectal adenocarcinoma No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence