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TBR1 has not been detected as a mutational cancer driver

TBR1
Ensembl id ENSG00000136535
Mutated samples
Coding Sequence 55 (0.8%)
Protein Affecting 38 (0.6%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all TBR1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 20 10 2.71
Lung adenocarcinoma No 7 7 1.79
Head and neck squamous cell carcinoma No 5 5 1.33
Medulloblastoma No 4 4 1.90
Lung squamous cell carcinoma No 4 4 2.30
Esophageal carcinoma No 3 2 1.37
Bladder carcinoma No 1 1 1.02
Neuroblastoma No 1 1 0.48
Uterine corpus endometrioid carcinoma No 1 1 0.43
Small cell lung carcinoma No 2 1 1.45
Glioblastoma multiforme No 1 1 0.26
Acute lymphocytic leukemia No 1 1 0.82
Hepatocarcinoma No 2 0 0.00
Renal clear cell carcinoma No 1 0 0.00
Serous ovarian adenocarcinoma No 1 0 0.00
Stomach adenocarcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence