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TBC1D8B has not been detected as a mutational cancer driver

TBC1D8B
Ensembl id ENSG00000133138
Mutated samples
Coding Sequence 90 (1.3%)
Protein Affecting 70 (1.0%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all TBC1D8B gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 27 15 4.07
Breast carcinoma No 12 11 0.96
Lung squamous cell carcinoma No 7 7 4.02
Lung adenocarcinoma No 4 4 1.02
Renal clear cell carcinoma No 5 4 0.96
Stomach adenocarcinoma No 6 4 2.48
Glioblastoma multiforme No 4 4 1.06
Hepatocarcinoma No 3 2 2.22
Bladder carcinoma No 2 2 2.04
Thyroid carcinoma No 2 2 0.62
Uterine corpus endometrioid carcinoma No 3 2 0.87
Serous ovarian adenocarcinoma No 2 2 0.63
Colorectal adenocarcinoma No 2 2 0.87
Head and neck squamous cell carcinoma No 2 2 0.53
Prostate adenocarcinoma No 1 1 0.41
Acute myeloid leukemia No 1 1 0.51
Neuroblastoma No 1 1 0.48
Chronic lymphocytic leukemia No 2 1 0.34
Lower grade glioma No 1 1 0.59
Pylocytic astrocytoma No 1 1 0.99
Small cell lung carcinoma No 1 1 1.45
Esophageal carcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence